11/29/2023 0 Comments Vaso constrict endo pharma![]() ![]() We said, ‘What’s happening?’ … I started to ask around, ‘Have you noticed this? This is phenomenal.’”ĭoctors and investigators together came to a startling realization: All but one of the 15 remembered recently injecting dissolved tablets of Opana ER, a recently reformulated time-release oral version of oxymorphone. Wahid Hanna, a hematologist at the University of Tennessee Medical Center, “and then in a few days or weeks we started to have another one, and another one, and another one. “We’d start treating a patient” for TTP, said Dr. By October 2012, 15 TTP cases in white IV drug users in Tennessee had been identified: seven from the same rural Northeast Tennessee county, five from other counties near it, and three from counties in Middle Tennessee. The nephrologist reported the cases in August 2012 to the Tennessee Department of Health, which then conducted a statewide investigation to see if there were similar instances. None had underlying infections that might cause the disorder. So when three people showed up at Kingsport’s Holston Valley Medical Center in 2012 with low blood platelet counts and the large purple skin lesions that are hallmarks of the rare disorder, the nephrologist there took notice.Īll three were white residents of a rural county in Northeast Tennessee. “It was something you wouldn’t wish on your worst enemy,” Wenger said. Untreated, TTP could quickly lead to sepsis, seizures, coma or loss of limbs. Kip Wenger, an emergency room physician with TeamHealth. It was unusual enough that when it appeared, “they dragged everybody in the hospital” in to have a chance to see it, said Dr. Smaller community hospitals might never see a case. Large teaching hospitals like the University of Tennessee Medical Center saw two or three cases a year of potentially deadly thrombotic thrombocytopenic purpura. ![]() It was a rare, aggressive blood disorder. Watch Video: FDA asks opioid maker to stop sales ![]()
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